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How it works
Retinoids slow the formation of skin epidermis by increasing the levels of a protein called Langerin (see diagram below). protects other proteins, called tyrosine kinases, on the epidermis from cell death.
The main active molecule in any skin medication is retinol:
The retinol dose of your retinoid depends on skin type (for example, dry requires lower retinol doses than oily skin). is also known as the active ingredient in vitamin A. You should not take retinol if you have severe liver disease or if you are at risk of severe liver damage.
The recommended amount of retinol is 4% to 6% of your daily retinol dose. To put this in perspective, 1 mg retinol gives you about 20-40 percent of your total daily dose, so you can use less than 1 mg retinol.
When used alone or if you are taking any other medications that interact with retinoid such as the anticoagulant warfarin or aspirin, you should use an alternative anticoagulant.
Because retinoids work by protecting and repairing cells, they can help slow or stop the progress of many types slow-growing diseases including psoriasis, acne and skin cancer. You should avoid using retinoids during pregnancy and lactation.
The most common side effects of retinol are:
Skin redness
Hair loss
Dry skin and peeling of
Dry, tight hair
The most common potential side effect is acne. The following are potential side effects that should be discussed with your doctor before you start treatment with your retinoid
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Have a history of skin conditions including acne, eczema, psoriasis and rashes.
Have a history of skin cancer or infection; have a high risk of having recurrence or a malignant condition
Have other skin problems that cause frequent or severe breakouts (such as:
Strawberry-blonde
Pale or blue-black skin with red darker spots
Sunburned skin with scarring (especially if you take drugs that make your skin more sensitive to the sun)
Have an abnormal cell turnover rate; such as abnormal proliferation rate, cell division, cellular function
Are using medicines that impair your immune system, such as the anticoagulant warfarin, immune-destroying drugs methotrexate and certain steroids
Have diabetes or kidney failure; retinoids should not be used during pregnancy and before the age of 30 if you have this risk.
How often you need to use your retinoids
Retinoids can be used on an as needed (prorated) basis or every other day. The main goal of monthly application is to keep your skin healthy and prevent further damage from aging so the pigment cells remain active.
When you are using your retinoid and taking care of the side effects described above, you may only need to use your medication on an as needed basis (for example, every other day).
Taking care of the side effects
Your doctor will likely start you off with the lowest dose of your retinoid and gradually increase it if needed.
The side effects listed below can be treated with an alternative chemical peel, such as a or laser peel. Talk to your doctor first find out if there is any medication you need to take with a chemical peel.
All of the symptoms listed below are temporary and usually go away on their own. However, some symptoms that can't be treated directly with the retinoid, such as:.
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